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One other important result was that patients treated with a single dose of prednisolone were statistically more likely to receive additional doses of the steroid compared to patients treated with 0.1 mg/day. The finding that patients treated using prednisolone were also more likely to have an increase in TSS was associated with lower TSS scores. Thus, a dose-response pattern was evident with treatment with TSS-lowering agents, suggesting that these agents may be useful in reducing TSS in the short term (Breslow and Jang, 1998). Several observations that might be taken into consideration for future research are a prospective, long-term study design (PES) and a placebo-controlled design. The primary focus of this paper is to outline the results of the PES and the mechanisms through which these interventions may be helpful. PES The purpose of a PES is to provide the best possible picture of the safety and clinical efficacy of an intervention, and this has been defined as a single visit in which the investigator has an opportunity to determine that a person is likely receiving an unsupplemented regimen. The PES is intended to provide safety information and is not intended to serve as a surrogate for the clinical efficacy evaluation of pharmacologic intervention (Mackie, 2004). The results from a PES may have a major impact on research studies which were originally designed to investigate clinical efficacy of a pharmacologic intervention. For example, a single PES may have important implications on the appropriateness of an investigation that was originally designed to investigate clinical efficacy of an immunosuppressive agent such as azathioprine (Lazar, 1975), which has been approved by the FDA for use in patients with advanced malignancy. For this reason, the following paragraphs are primarily intended to discuss study design and safety in relation to prednisolone therapy. The PES is typically performed by health care providers. The investigator takes the patients' medical history, clinical symptoms, clinical laboratory tests, and laboratory measurements and evaluates the clinical status using a structured questionnaire. An adverse event has to be reported by the patient or by the health care provider during the assessment and intervention (Mackie, 2004). In a PES evaluation, the investigator may ask patients to provide a written report of any symptom(s) that may be related to their drug treatment regimen and to provide a complete and detailed report of the medication(s) used in the previous 6-12 months. A report of drug-related adverse events is provided to the investigator when the results of laboratory tests, laboratory findings as well as clinical information were available. If the results of any of these tests cannot be Related Article:

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